首部电影以校园故事为主：莉萨（Lissa）是吸血鬼家族的纯血公主，她拥有极罕见且强大的魔法。她就读于名为圣弗拉米尔的吸血鬼学院，在这里她要时时提防莫里（Moroi）家族的袭击。当然莉萨公主并非孤身一人，她有好朋友萝斯·海瑟薇（RoseHathaway）和监护人迪米特里（Dimitri）助阵，后者还和她发生了一段浪漫的爱情故事。

Atthestartofhighschool,Piper,Sophie,IsabellaandHonorthinktheywillbebestfriendsforever,sotheysinkatimecapsuleinthelakewithalistofthingstheywanttodobeforegraduation.Bysenioryear,theyhavegonetheirseparateways.Piperhasturnedintotheclassclown,partygirlwhoneverpassesupadrink.Sophiepledgestostayavirginuntilsheismarriedandhascreatedapurityapp.Isabellaisthefeministfemmefatalewho’stheeditorofazine.AndHonoristheprideandjoyofthecommunity.Herdreamofbeingaprofessionalballerinaistakingoff.Butwhentragedystrikes,theformerBFFsmustreunite,breakopenthecapsuleandcompletethepre-graduationbucketlist.